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基于Box-Behnken Design優(yōu)化當(dāng)歸中鉛元素的測(cè)定方法研究
王昭國(guó)
張掖市質(zhì)量檢驗(yàn)檢測(cè)研究院食品檢驗(yàn)檢測(cè)中心 甘肅 張掖 73400
Optimization of Determination Method of Lead in Angelica Based on Box-Behnken Desig
WANG Zhaoguo
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摘要：
通過微波消解法，原子吸收分光光度計(jì)對(duì)當(dāng)歸中鉛的吸光度進(jìn)行測(cè)定，采用Box-Behnken Design設(shè)計(jì)試驗(yàn)方法以確定最佳儀器分析條件；通過單因素試驗(yàn)，選取灰化溫度、灰化時(shí)間、原子化溫度、原子化時(shí)間四因素進(jìn)行三水平試驗(yàn)，通過Box-Behnken Design建立數(shù)學(xué)模型，方差分析、響應(yīng)曲面分析、愿望函數(shù)優(yōu)化尋求最佳條件；結(jié)果顯示建立的數(shù)學(xué)模型R2=0.9671，R2Adj =0.9342說明該模型具有很好的可信度，可用此模型進(jìn)行預(yù)測(cè)，變異系數(shù) CV %=3.62 %，表明在該試驗(yàn)條件下，變異程度較小，該模型具有較好的重復(fù)性，當(dāng)灰化溫度為525℃，灰化時(shí)間為20s，原子化溫度為1550℃，原子化時(shí)間為5s時(shí)吸光度最大為0.24；因此，本研究可為原子吸收分光光度計(jì)測(cè)定鉛元素提供很好的方法理論基礎(chǔ)。
關(guān)鍵詞: 鉛元素 原子吸收分光光度計(jì) 響應(yīng)面法 愿望函數(shù)
Abstract:
The absorbance of lead in flour was determined by microwave digestion method and atomic absorption spectrophotometer. Box-behnken Design was used to determine the best instrumental analysis conditions. Through the single-factor test, the four factors of ashing temperature, ashing time, atomization temperature and atomization time were selected for the three-level test. The mathematical model was established by Box-Behnken Design, and the optimal conditions were sought by variance analysis, response surface analysis and desire function optimization. Results show that the established mathematical model of the R2=0.9671，R2Adj =0.9342 shows that the model has good credibility, this model could be used to predict the coefficient of variation CV % = 3.08%, indicates that under the condition of the experiment, variation is small, the model has good repeatability, when ashing temperature is 525℃, ashing time is 20s, atomization temperature is 1550℃, atomization time for 5s absorbance maximum 0.24; Therefore, this study can provide a good theoretical basis for the determination of lead by atomic absorption spectrophotometer.
Key words: Lead element Atomic absorption spectrophotometer Box-Behnken Numericai
出版日期: 2021-03-25
ZTFLH: R155.5
引用本文:
王昭國(guó). 基于Box-Behnken Design優(yōu)化當(dāng)歸中鉛元素的測(cè)定方法研究 [J]. 吉林化工學(xué)院學(xué)報(bào), 2021, 38(3): 7-12.
WANG Zhaoguo. Optimization of Determination Method of Lead in Angelica Based on Box-Behnken Desig . Journal of Jilin Institute of Chemical Technology, 2021, 38(3): 7-12.
本文鏈接：https://emuchong.com/111401/
基于Box-Behnken Design優(yōu)化當(dāng)歸中鉛元素的測(cè)定方法研究 |
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